The study investigated teaching Basic Science for probable global challenges and sustainable development in junior secondary school in Ekiti, Nigeria. This was a descriptive survey research which was questionnaire based. The population of the study was Junior Secondary School III (JSS III) Basic Science students of public secondary schools in Ekiti State, Nigeria. The sample consisted of 150 students drawn from two public secondary schools in Ikere Local Government of Ekiti State. Stratified random sampling was used to select the sample. The instrument used for data collection was structured questionnaire. The instrument was subjected to validity and reliability mechanisms. The reliability of the instruments was determined using Test-Retest method on a sample similar to the study population but not the exact same participants. Three research questions were generated and tested using chi-square statistical analysis at 0.05 level of significance. The findings of the study revealed students’ lacked the required