The study investigated the influence of manipulative skills on the teaching and learning of Basic Science in Secondary Schools in Ikere Local Government Area of Ekiti State. The study adopted descriptive research design of survey type. The population of this study comprised of Basic Science teachers and Junior Secondary class three (3) students in Ikere Local Government Area of Ekiti State. The sample of study consisted of ten Basic Science teachers and ninety Junior secondary class three students selected from the ten secondary schools in Ikere Local Government Area of Ekiti using simple random sampling techniques. The total sample used for the study were 100 respondents. Self-structured questionnaire was used to collect data for the study. The face and content validity of the instrument was done by experts in Test and Measurement and Integrated Science Education. The reliability of the instrument was established through the test re-test method, the two tests scores were thereafter correlated using Pearson product moment correlation which yielded coefficient value of 0.80 for self-structured questionnaire on manipulative skills on the teaching and learning of Basic Science in Secondary Schools. The researcher personally administered the questionnaire to the respondents. Data collected were analysed using descriptive and inferential statistics. The findings of the study revealed among others that most of the common manipulative skills used by Basic Science teachers influence the teaching and learning of Basic Science in schools. It was concluded among others that the failure rate of students will be curtailed if Basic Science teachers were made to utilize appropriate and relevant manipulative skills during the teaching and learning process of Basic science in secondary schools. Based on the findings of the study, the following recommendation were made among others that Basic Science teachers should endeavour to use and try to improvise instructional materials for effective teaching of Basic Science in the secondary schools. Government should ensure the adequate employment of dedicated and qualified Basic Science teachers to teach the subject in all secondary schools in the study area and in the state.